Conventional treatment of kidney disease, mostly used to control urinary protein, urine occult blood drugs, such as hormones, cyclophosphamide, TWP, cyclosporine A, MMF, will damage the glomerular basement membrane plugging up loopholes, from the surface watching the disease was brought under control, urine protein, occult blood temporarily decreased or disappeared, patients mistakenly believe that the condition improved. This is very unscientific! Discharge instructions damaging substances are self-help reflect the kidneys, and urine protein, urine occult blood to some extent, it is a surface phenomenon of this process. Therefore, the destruction of the basement membrane plugging up loopholes, although the urine test was negative, but a large number of immune complexes to the kidney and damaging substances blocked in and continue to damage the kidneys, and its role is tantamount to "stay behind closed doors Kou!" Accelerated kidney damage inside the final years or relapse or worsening after ten years, the development of chronic renal failure, uremia, regret!
Similarly, patients with chronic renal failure, application control diet, reduced activity, dialysis (hemodialysis, peritoneal dialysis, dialysis gut, colon dialysis) and other measures to serum creatinine, blood urea nitrogen temporary decline, the disease is considered better, It can also delay the timing of treatment. If there is no change in renal pathology structure fundamentally improve renal perfusion, recovery of renal function, even if the serum creatinine, blood urea nitrogen decreased, due to the glomerular filtration rate not be raised until the residual renal unit the spent and exhausted, blood creatinine, blood urea nitrogen will suddenly soaring, the condition deteriorated sharply, and finally to rely on dialysis or a kidney transplant to sustain life.
Most patients with kidney disease, and even some medical workers, saw serum creatinine, blood urea nitrogen dropped that condition is getting better, mistakenly serum creatinine, blood urea nitrogen decreased kidney itself better as judged by a standard that is not objective . So how can you know what is the real improvement in kidney disease? We must first understand the serum creatinine, blood urea nitrogen is how to generate and exhausted? Because usually serum creatinine, blood urea nitrogen produced from human muscle catabolism and diet (meat, eggs, milk and other protein intake) to produce. Most of it is discharged from the kidney excretion in urine, a small part of the discharge from the stool, which can be seen when the patient uses a reduced activity or diet protein intake or increased intestinal detoxification methods, can make temporary decline in serum creatinine urea nitrogen, then check kidney function is "better" but precisely nothing to do with the kidneys. Because kidney function itself has not been recovered in urine did not increase detoxification, so instead of treatment outcome after renal improvement. And With this treatment leads to serum creatinine, blood urea nitrogen began to decline, it is also the beginning of renal parenchymal damage when aggravated it. When kidney residual renal unit the spent and exhausted, these drugs will no longer be maintained, then usually maintained within a certain range of serum creatinine, blood urea nitrogen will suddenly soaring, worsening the disease into the period, the patient helpless, finally helplessly into the painful and costly conventional dialysis or kidney transplant to sustain life in the road.
If the control urinary protein, occult blood drugs, the destruction of the basement membrane plugging up loopholes, urine protein, occult blood was controlled, but also the damaging substances and immune complexes in glomeruli clogged inside, on the surface improved urine test, it seems her condition improved, in fact, the kidney since these substances can not be discharged, continue to accumulate, continuing to stimulate the kidneys and cause renal damage diffuse mesangial proliferation, segmental sclerosis, glomerulosclerosis, crescent formation, these pathological damage is fatal kidney damage. Note change: inflammatory hyperplasia → → → hardening → necrosis of kidney failure. So dedicated ECT examination revealed kidney: kidney function continued to decline, thus proving that the simple use of control urinary protein, occult blood treatment has accelerated the destruction of the substance above the kidney, made it worse, not better!
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